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DimAbs For I/O

Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation); At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.

Our rabbit DimAb® recombinant monoclonal antibody development platform, by using fully validated functional recombinant proteins as antigens to immunize rabbits, can generate functional DimAb monoclonal antibody clones in high chances. Since this technology can directly isolate IgG gene from positive rabbit B cells, it will significantly shorten the research and development time without worrying about the loss of hybridoma cells.

Product targets:

2B4
4-1BB
4-1BB-L
SIRPα
B7-H3
BCMA
CD123
CD48
CD138
CD22
CD27
GITRL
CD28
CD38
CD47
CS1
GPRC5D CTLA-4 MSLN TROP2
GITR

Free trial available! Click to apply!

Product Advantage:

High affinity and high specificity


          Figure 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

            Multiple candidate clones of a single target showed high selectivity

                  Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
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