Compared with other animals, rabbits have a unique process of B cell development and are farther apart than rodents and humans. In addition, rabbit B cells have a dual affinity maturation mechanism, including gene conversion and SHM (somatic hypermutation); At the same time, the protein structure of rabbit IgG is different from that of mouse IgG, which is reflected in that it has only one subtype of IgG and its CDR3 region is longer than mouse CDR3. These differences make rabbit produce monoclonal antibodies with higher affinity and specificity.
Our rabbit DimAb® recombinant monoclonal antibody development platform, by using fully validated functional recombinant proteins as antigens to immunize rabbits, can generate functional DimAb monoclonal antibody clones in high chances. Since this technology can directly isolate IgG gene from positive rabbit B cells, it will significantly shorten the research and development time without worrying about the loss of hybridoma cells.
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