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Human BAFF-R Protein, hFc Tag

产品概述
Catalog Number PME100503
Package 10 μg ¥600.00 ; 50 μg ¥2350.00 ; 100 μg ¥3380.00
Description Recombinant Human BAFF-R protein with C-terminal human Fc
Synonyms BAFFR,TNFRSF13C,BAFF-R,BROMIX,CD268,CVID4,prolixin
Uniprot ID Q96RJ3
Expression Host HEK293
Tag C-Human Fc tag
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 32.7 kDa after removal of the signal peptide.The apparent molecular mass of BAFF-R-hFc is approximately 35-55 kDa due to glycosylation.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

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Figure 1. Human BAFF-R Protein, hFc Tag on SDS-PAGE under reducing condition.

Background B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
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