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Human CD130 Protein, hFc Tag

产品概述
Catalog Number PME100811
Package 10 μg ¥600.00 ; 50 μg ¥2350.00 ; 100 μg ¥3380.00
Description Recombinant human CD130 protein with C-terminal human Fc tag
Synonyms CD130, CDW130, GP130, IL-6RB
Delivery 4-6 weeks
Uniprot ID P40189
Expression Host HEK293
Tag C-Human Fc
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 91.19 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images


Background The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
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