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Anti-CD40 antibody(DM100), Rabbit mAb

产品概述
Clone ID DM100
Immunogen Recombinant human CD40 (Glu21-Arg193) (PME100015) produced by using human HEK293 cells
Buffer Preservative: 0.1% Procline 300
Constituents: 50% Glycerol; PBS,pH 7.4; 0.1% BSA
Catalog Number DME100100
Package 10 μl ¥600.00 ; 100 μl ¥3880.00
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Host Species Rabbit
IgG type Rabbit IgG
Clonality Monoclonal
Formulation Liquid
Purification Purified from cell culture supernatant by affinity chromatography
Reactivity Human
Applications ELISA,Flow Cyt
Recommended Dilutions ELISA 1/5000-10000;Flow Cyt  1/100
Storage Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

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Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CD40 protein, mFc-His tagged protein (PME100015) can bind Rabbit anti-CD40 monoclonal antibody (clone: DM100) in a linear range of 0.64-80 ng/ml.

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Figure 2. Flow cytometry analysis with Anti-CD40 (DM100) on Expi293 cells transfected with human CD40 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

Background This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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