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Human B7-2 Protein, mFc-His Tag

产品概述
Catalog Number PME100034
Package 10 μg ¥600.00 ; 50 μg ¥2350.00 ; 100 μg ¥3380.00
Description Recombinant human B7-2 protein with C-terminal mouse Fc and 6×His tag
Synonyms CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Uniprot ID P42081
Expression Host HEK293
Tag C-Mouse Fc and 6×His tag
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 52.4 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

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Figure 1. Human B7-2 Protein, mFc-His Tag on SDS-PAGE under reducing condition.

Background This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
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