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Human CD38 Protein, hFc-His Tag

Product Overview
Catalog Number PME100004
Package 10 μg $70.00; 50 μg $280.00;100 μg $380.00
Description Recombinant human CD38 protein with C-terminal human Fc and 6×His tag
Synonyms CD38, T10, cADPr hydrolase 1
Delivery In Stock
Uniprot ID P28907
Expression Host HEK293
Tag C-Human Fc and 6×His tag
Molecular Characterization
Molecular Weight The protein has a predicted molecular mass of 70-72 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

Figure 1. Human CD38, hFc-His Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CD38, hFc-His tagged protein (PME100004) can bind Anti-CD38 Neutralizing antibody (BME100004) in a linear range of 0.98-64.14 ng/ml.
Background CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
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