Human CD38 Protein, hFc-His Tag
|Package||10 μg $70.00; 50 μg $280.00;100 μg $380.00|
|Description||Recombinant human CD38 protein with C-terminal human Fc and 6×His tag|
|Synonyms||CD38, T10, cADPr hydrolase 1|
|Tag||C-Human Fc and 6×His tag|
|Molecular Weight||The protein has a predicted molecular mass of 70-72 kDa after removal of the signal peptide.|
|Purity||The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.|
|Formulation & Reconstitution||Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.|
|Storage||Store at -20°C to -70°C for 12 months in lyophilized state|
|Usage||Research use only|
Figure 1. Human CD38, hFc-His Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CD38, hFc-His tagged protein (PME100004) can bind Anti-CD38 Neutralizing antibody (BME100004) in a linear range of 0.98-64.14 ng/ml.
|Background||CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.|