Anti-CTLA4, Rabbit pAb
| Clone ID | DM8 |
|---|---|
| Immunogen | Recombinant human SIRPα (Glu31-Arg370) produced by using human HEK293 cells |
| Predicted Molecular Weight | 66.9 kDa |
| Catalog Number | DME200012 |
|---|---|
| Package | |
| Synonyms | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Host Species | Rabbit |
| IgG type | IgG |
| Clonality | Rabbit polyclonal |
| Formulation | Liquid |
| Purification | Antigen affinity purification |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA 5000-10000; IHC 25-100 |
| Storage | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Usage | Research use only |
| Images |
The image1 is immunohistochemistry of paraffin-embedded Human liver cancer tissue using DME200012(CTLA4 Antibody) at dilution 1/20, the image2 is treated with synthetic peptide. (Original magnification: ×200)
The image3 is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using DME200012(CTLA4 Antibody) at dilution 1/20, the image4 is treated with synthetic peptide. (Original magnification: ×200) |
| Background | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
| Datasheet | Download | COA | Download |
|---|---|---|---|
| MSDS | Download | ||
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