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Anti-CTLA4, Rabbit pAb

Product Overview
Clone IDDM8
ImmunogenRecombinant human SIRPα (Glu31-Arg370) produced by using human HEK293 cells
Predicted Molecular Weight66.9 kDa
Catalog Number DME200012
Package
Synonyms CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
Host Species Rabbit
IgG type IgG
Clonality Rabbit polyclonal
Formulation Liquid
Purification Antigen affinity purification
Reactivity Human, Mouse
Applications ELISA, IHC
Recommended Dilutions ELISA 5000-10000; IHC 25-100
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Usage Research use only
Images

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The image1 is immunohistochemistry of paraffin-embedded Human liver cancer tissue using DME200012(CTLA4 Antibody) at dilution 1/20, the image2 is treated with synthetic peptide. (Original magnification: ×200)

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The image3 is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using DME200012(CTLA4 Antibody) at dilution 1/20, the image4 is treated with synthetic peptide. (Original magnification: ×200)

Background This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
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