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Anti-FLT3, Rabbit pAb

Product Overview
Clone IDDM8
ImmunogenRecombinant human SIRPα (Glu31-Arg370) produced by using human HEK293 cells
Predicted Molecular Weight66.9 kDa
Catalog Number DME200015
Package
Synonyms FLK2; STK1; CD135; FLK-2
Host Species Rabbit
IgG type IgG
Clonality Rabbit polyclonal
Formulation Liquid
Purification Antigen affinity purification
Reactivity Human, Mouse, Rat
Applications ELISA, WB, IHC
Recommended Dilutions ELISA 1000-2000; WB 200-1000; IHC 25-100
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Usage Research use only
Images

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The image1 is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DME200015(FLT3 Antibody) at dilution 1/30, the image2 is treated with fusion protein. (Original magnification: ×200)

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The image3 is immunohistochemistry of paraffin-embedded Human liver cancer tissue using DME200015(FLT3 Antibody) at dilution 1/30, the image4 is treated with fusion protein. (Original magnification: ×200)

The image5: Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, 231 cells, Primary antibody: DME200015(FLT3 Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds

Background This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
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