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Human PD-1 Protein, mFc-His tag

Product Overview
Catalog Number PME100025
Package 10 μg $60.00 ; 50 μg $265.00 ; 100 μg $378.00
Description Recombinant human PD-1 protein with C-terminal mouse Fc and 6×His tag
Synonyms PDCD1, PD1, CD279, SLEB2
Uniprot ID Q15116
Expression Host HEK293
Tag C-Mouse Fc and 6xHis tag
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 43.5 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

Figure 1. Human PD-1 Protein, mFc-His Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human PD1, mFc-His tagged protein (PME100025) can bind Anti-PD-1 Neutralizing antibody (BME100006) in a linear range of 0.24-6.49 ng/ml.

Background This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
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