Human TIM3 Protein, mFc-His Tag
| Catalog Number | PME100030 |
|---|---|
| Package | 10 μg $60.00 ; 50 μg $265.00 ; 100 μg $378.00 |
| Description | Recombinant human TIM3 protein with C-terminal mouse Fc and 6×His tag |
| Synonyms | HAVCR2, TIM3, TIMD3, FLJ14428, KIM3 |
| Uniprot ID | Q8TDQ0 |
| Expression Host | HEK293 |
| Tag | C-Mouse Fc and 6xHis tag |
| Molecular Characterization |
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| Molecular Weight | The protein has a predicted molecular mass of 47.5 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Storage | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage | Research use only |
| Images |
Figure 1. Human TIM3 Protein, mFc-His Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human TIM3, mFc-His tagged protein (PME100030) can bind Anti-TIM3 Neutralizing antibody (BME100008) in a linear range of 0.64-80 ng/ml. |
| Background | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. |
| Datasheet | Download | COA | Download |
|---|---|---|---|
| MSDS | Download | ||
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