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Human ACE2 Protein, mFc Tag

Product Overview
Catalog Number PME100072
Description Recombinant human ACE2 protein with C-terminal mouse Fc tag
Synonyms ACE-2, ACEH, ACE2
Expression Host HEK293
Tag C-Mouse Fc tag
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 109.7 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 23 % trehalose is added as protectants before lyophilization.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

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Figure 1. Human ACE2 Protein, mFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well)  S-RBD, mFc tagged protein (PME100497) can bind Human ACE2, hFc Tagged protein(PME100072) in a linear range of 7.81-87.7 ng/ml.

Background The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
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