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Human TLR4 Protein, hFc Tag

Product Overview
Catalog Number PME101021
Package 10 μg $60.00 ; 50 μg $235.00 ; 100 μg $338.00
Description Recombinant human TLR4 protein with C-terminal human Fc tag
Synonyms ARMD10, CD284, TLR-4, TOLL
Delivery 4-6 weeks
Uniprot ID O00206
Expression Host HEK293
Tag C-Human Fc
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 92.4 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images


Background The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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