Clone ID | DMC485 |
---|---|
Target | |
Synonyms | CDH16; HPT-1; HPT1 |
Host Species | Rabbit |
Description | Anti-CDH17 antibody(DMC485); IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | Q12864 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | This gene is a member of the cadherin superfamily; genes encoding calcium-dependent; membrane-associated glycoproteins. The encoded protein is cadherin-like; consisting of an extracellular region; containing 7 cadherin domains; and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts; acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq; Jan 2009] |
Usage | Research use only |
Anti-CDH17 antibody(DMC485); IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-CDH17 (DMC485) on Expi293 cells transfected with human CDH17 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human CDH17 mAb(DMC100485).
(A) DMC100485 does not bind to 293T cells that do not express CDH17.
(B) A clear peak shift of DMC100485 was seen compared to the control when incubated with CDH17-expressing HT55 cells, indicating strong binding of DMC100485 to CDH17. Antibodies were incubated at 2 μg/mL.
(C) A clear peak shift of DMC100485 was seen compared to the control when incubated with CDH17-expressing AGS cells, indicating strong binding of DMC100485 to CDH17. Antibodies were incubated at 2 μg/mL.