DiLibrary™ mammalian display platform for antibody engineering
Antibody humanization is important for the therapeutic antibody development especially for the candidate antibodies derived from animal sources, such as mouse or rabbit. DIMA Biotech has developed a proprietary mammalian display platform for the antibody humanization, called DiLibrary™ humanization platform. With this platform, we can deliver a panel of humanized variants from your candidate clone with comparable activity to the parent antibody. In addition to the affinity of the antibodies, we also focused on the humanized antibodies with high expression and low aggregation levels, which is required for the downstream large-scale production of the therapeutic antibody. Our mammalian display system can help us screen out the most promising humanized variant with the real functional data of the candidate antibodies.
Case 1: Humanization of Anti-BCMA rabbit mAb
By using DiLibrary™ display platform, we have successfully obtained humanized antibodies with increased binding affinity (Hu-BCMA3 shows around 18-fold increase).
Case 2: Humanization of Anti-CEACAM5 rabbit mAb
By using DiLibrary™ display platform, we have successfully obtained humanized antibodies with increased binding affinity (Hu-CEACAM5-02 shows around 19-fold increase).