Synthetic Nanodisc: An Innovative Solution For Multipass Transmembrane Proteins

Nanodisc is a disc structure with a diameter around 10nm, which can keep transmembrane proteins in the environment of lipid bilayer, maintaining its conformation and biological functions.

Unlike other membrane scaffold protein (MSP) Nanodisc on the market, synthetic Nanodisc developed by DIMA Bio can be prepared directly from the mammalian cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified by affinity purification.

Request Your Target Protein in Nanodisc


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    Nanodisc Platform

    Off-the-shelf Target Proteins

    The diagram of nanodisc

    Advantages:
    ・Full length membrane proteins with high purity
    ・High solubility in aqueous solutions
    ・High stability, lyophilized powder stable at room temperature 
    ・Proteins are in a native membrane environment and remain biologically active
    ・No detergent, useful for cell-based assays
    ・No MSP backbone proteins

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    Applications:
    ・ELISA
    ・SPR affinity analysis
    ・Phage display screening
    ・Immunization
    ・Cell based assays
    ・Protein crystal structure analysis

    Case Studies

    Human MDR-1 full length protein-synthetic nanodisc (Cat. FLP100029) 12 transmembrane protein

    Human GPRC5D full length protein-synthetic nanodisc (Cat. FLP100011) 7 transmembrane protein

    Human CLDN6 full length protein-synthetic nanodisc (Cat. FLP100008) 4 transmembrane protein

    Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

    High Activity

    ELISA

    pages-Full length Membrane Proteins High Activity High Stability 4

    High Stability

    Lyophilization test

    pages-Full length Membrane Proteins High Activity High Stability 6

    Accelerated Test (Lyophilized Powder)

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    Full length protein-synthetic nanodisc

    TargetCATALOG NUMBERPRODUCT NAME
    ACKR3FLP100095Human ACKR3 full length protein-synthetic nanodisc
    ADGRD1FLP100127Human ADGRD1 full length protein-synthetic nanodisc
    ADGRE1FLP100055Human ADGRE1 full length protein-synthetic nanodisc
    ADGRE2FLP100090Human ADGRE2 full length protein-synthetic nanodisc
    ADGRE5FLP100117Human ADGRE5 full length protein-synthetic nanodisc
    ADGRG1FLP100104Human ADGRG1 full length protein-synthetic nanodisc
    ADGRG2FLP100107Human ADGRG2 full length protein-synthetic nanodisc
    ADORA2AFLP100020Human ADORA2A full length protein-synthetic nanodisc
    ADORA2BFLP100093Human ADORA2B full length protein-synthetic nanodisc
    AGTR1FLP100098Human AGTR1 full length protein-synthetic nanodisc
    APLNRFLP100132Human APLNR full length protein-synthetic nanodisc
    BDKRB2FLP100123Human BDKRB2 full length protein-synthetic nanodisc
    C5AR1FLP100086Human C5AR1 full length protein-synthetic nanodisc
    C5AR2FLP100069Human C5AR2 full length protein-synthetic nanodisc
    CAV1FLP100142Human CAV1 full length protein-synthetic nanodisc
    CB1FLP100023Human CB1 full length protein-synthetic nanodisc
    CB2FLP100138Human CB2 full length protein-synthetic nanodisc
    CCR1FLP100094Human CCR1 full length protein-synthetic nanodisc
    CCR2FLP100028Human CCR2 full length protein-synthetic nanodisc
    CCR3FLP100075Human CCR3 full length protein-synthetic nanodisc
    CCR4FLP100024Human CCR4 full length protein-synthetic nanodisc
    CCR5FLP100100Human CCR5 full length protein-synthetic nanodisc
    CCR6FLP100059Human CCR6 full length protein-synthetic nanodisc
    CCR7FLP100060Human CCR7 full length protein-synthetic nanodisc
    CCR8FLP100037Human CCR8 full length protein-synthetic nanodisc
    CCR9FLP100061Human CCR9 full length protein-synthetic nanodisc
    CD151FLP100071Human CD151 full length protein-synthetic nanodisc
    CD20FLP100027Human CD20 full length protein-synthetic nanodisc
    CD36FLP100044Human CD36 full length protein-synthetic nanodisc
    CD37FLP100042Human CD37 full length protein-synthetic nanodisc
    CD47FLP100039Human CD47 full length protein-synthetic nanodisc
    CD63FLP100030Human CD63 full length protein-synthetic nanodisc
    CD81FLP100050Human CD81 full length protein-synthetic nanodisc
    CHRM2FLP100111Human CHRM2 full length protein-synthetic nanodisc
    CLDN18.2FLP100014Human CLDN18.2 full length protein-synthetic nanodisc
    CLDN2FLP100082Human CLDN2 full length protein-synthetic nanodisc
    CLDN3FLP100078Human CLDN3 full length protein-synthetic nanodisc
    CLDN4FLP100083Human CLDN4 full length protein-synthetic nanodisc
    CLDN5FLP100079Human CLDN5 full length protein-synthetic nanodisc
    CLDN6FLP100008Human CLDN6 full length protein-synthetic nanodisc
    CLDN7FLP100080Human CLDN7 full length protein-synthetic nanodisc
    CLDN9FLP100081Human CLDN9 full length protein-synthetic nanodisc
    CLPTM1FLP100110Human CLPTM1 full length protein-synthetic nanodisc
    CMKLR1FLP100126Human CMKLR1 full length protein-synthetic nanodisc
    CMTM6FLP100058Human CMTM6 full length protein-synthetic nanodisc
    CX3CR1FLP100115Human CX3CR1 full length protein-synthetic nanodisc
    CXCR1FLP100091Human CXCR1 full length protein-synthetic nanodisc
    CXCR2FLP100066Human CXCR2 full length protein-synthetic nanodisc
    CXCR3FLP100053Human CXCR3 full length protein-synthetic nanodisc
    CXCR4FLP100074Human CXCR4 full length protein-synthetic nanodisc
    CXCR5FLP100067Human CXCR5 full length protein-synthetic nanodisc
    CXCR6FLP100124Human CXCR6 full length protein-synthetic nanodisc
    ENTPD1FLP100065Human ENTPD1 full length protein-synthetic nanodisc
    ENTPD2FLP100051Human ENTPD2 full length protein-synthetic nanodisc
    ESYT1FLP100077Human ESYT1 full length protein-synthetic nanodisc
    F2RL1FLP100036Human F2RL1 full length protein-synthetic nanodisc
    F2RL3FLP100114Human F2RL3 full length protein-synthetic nanodisc
    FFAR1FLP100134Human FFAR1 full length protein-synthetic nanodisc
    FSHRFLP100047Human FSHR full length protein-synthetic nanodisc
    FZD10FLP100052Human FZD10 full length protein-synthetic nanodisc
    FZD4FLP100139Human FZD4 full length protein-synthetic nanodisc
    FZD7FLP100109Human FZD7 full length protein-synthetic nanodisc
    GCGRFLP100085Human GCGR full length protein-synthetic nanodisc
    GIPRFLP100130Human GIPR full length protein-synthetic nanodisc
    GLP1RFLP100121Human GLP1R full length protein-synthetic nanodisc
    GLP2RFLP100113Human GLP2R full length protein-synthetic nanodisc
    GNRHRFLP100092Human GNRHR full length protein-synthetic nanodisc
    GPR132FLP100116Human GPR132 full length protein-synthetic nanodisc
    GPR20FLP100108Human GPR20 full length protein-synthetic nanodisc
    GPR55FLP100054Human GPR55 full length protein-synthetic nanodisc
    GPR65FLP100103Human GPR65 full length protein-synthetic nanodisc
    GPR75FLP100031Human GPR75 full length protein-synthetic nanodisc
    GPR84FLP100129Human GPR84 full length protein-synthetic nanodisc
    GPR87FLP100062Human GPR87 full length protein-synthetic nanodisc
    GPRC5DFLP100011Human GPRC5D full length protein-synthetic nanodisc
    GRM2FLP100135Human GRM2 full length protein-synthetic nanodisc
    GRM7FLP100119Human GRM7 full length protein-synthetic nanodisc
    GRPRFLP100118Human GRPR full length protein-synthetic nanodisc
    HCRTR1FLP100099Human HCRTR1 full length protein-synthetic nanodisc
    HRH3FLP100133Human HRH3 full length protein-synthetic nanodisc
    KCNK9FLP100063Human KCNK9 full length protein-synthetic nanodisc
    LGR4FLP100072Human LGR4 full length protein-synthetic nanodisc
    LGR5FLP100073Human LGR5 full length protein-synthetic nanodisc
    LGR6FLP100068Human LGR6 full length protein-synthetic nanodisc
    MC4RFLP100122Human MC4R full length protein-synthetic nanodisc
    MDR-1FLP100029Human MDR-1 full length protein-synthetic nanodisc
    MFSD13AFLP100106Human MFSD13A full length protein-synthetic nanodisc
    MLC1FLP100087Human MLC1 full length protein-synthetic nanodisc
    MRGPRX2FLP100105Human MRGPRX2 full length protein-synthetic nanodisc
    NPC1L1FLP100089Human NPC1L1 full length protein-synthetic nanodisc
    NTSR1FLP100131Human NTSR1 full length protein-synthetic nanodisc
    OR2H1FLP100025Human OR2H1 full length protein-synthetic nanodisc
    OR52D1FLP100137Human OR52D1 full length protein-synthetic nanodisc
    P2RX7FLP100049Human P2RX7 full length protein-synthetic nanodisc
    PLA2R1FLP100147Human PLA2R1 full length protein-synthetic nanodisc
    PROKR1FLP100102Human PROKR1 full length protein-synthetic nanodisc
    PROM1FLP100046Human PROM1 full length protein-synthetic nanodisc
    PTGDR2FLP100125Human PTGDR2 full length protein-synthetic nanodisc
    PTGER2FLP100096Human PTGER2 full length protein-synthetic nanodisc
    PTGER4FLP100097Human PTGER4 full length protein-synthetic nanodisc
    PVRIGFLP100041Human PVRIG full length protein-synthetic nanodisc
    SCARB1FLP100112Human SCARB1 full length protein-synthetic nanodisc
    SLC1A5FLP100057Human SLC1A5 full length protein-synthetic nanodisc
    SLC25A4FLP100032Human SLC25A4 full length protein-synthetic nanodisc
    SLC2A12FLP100084Human SLC2A12 full length protein-synthetic nanodisc
    SLC2A4FLP100064Human SLC2A4 full length protein-synthetic nanodisc
    SLC39A6FLP100056Human SLC39A6 full length protein-synthetic nanodisc
    SLC4A7FLP100076Human SLC4A7 full length protein-synthetic nanodisc
    SLC7A11FLP100048Human SLC7A11 full length protein-synthetic nanodisc
    SSTR2FLP100013Human SSTR2 full length protein-synthetic nanodisc
    STEAP1FLP100070Human STEAP1 full length protein-synthetic nanodisc
    STEAP2FLP100043Human STEAP2 full length protein-synthetic nanodisc
    STING1FLP100040Human STING1 full length protein-synthetic nanodisc
    TLR2FLP100140Human TLR2 full length protein-synthetic nanodisc
    TLR4FLP100141Human TLR4 full length protein-synthetic nanodisc
    TLR5FLP100143Human TLR5 full length protein-synthetic nanodisc
    TLR7FLP100144Human TLR7 full length protein-synthetic nanodisc
    TLR9FLP100146Human TLR9 full length protein-synthetic nanodisc
    TM4SF1FLP100022Human TM4SF1 full length protein-synthetic nanodisc
    TMCC3FLP100101Human TMCC3 full length protein-synthetic nanodisc
    TRPA1FLP100033Human TRPA1 full length protein-synthetic nanodisc
    TRPV1FLP100128Human TRPV1 full length protein-synthetic nanodisc
    TSHRFLP100045Human TSHR full length protein-synthetic nanodisc
    TSPAN33FLP100035Human TSPAN33 full length protein-synthetic nanodisc
    TSPAN8FLP100088Human TSPAN8 full length protein-synthetic nanodisc
    UTS2RFLP100136Human UTS2R full length protein-synthetic nanodisc
    XCR1FLP100120Human XCR1 full length protein-synthetic nanodisc