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Human Vitronectin (N-Truncated, C-6His) Protein

Price: 10 μg $60.00 ; 50 μg $190.00

SKU: PME30026 Category:
Product Data
Target

Synonyms

Complement S-protein; epibolin; Serum Spreading Factor; Serum-spreading factor; Somatomedin B; S-protein; V75; Vitronectin; VN; VNT; VTN
Package

10 μg $60.00 ; 50 μg $190.00
Description

Recombinant Human Vitronectin is produced by our Mammalian expression system and the target gene encoding Val62-Leu478 is expressed with a 6His tag at the C-terminus.
Delivery

In Stock
Uniprot ID

AAH05046.1
Expression Host

HEK293
Tag

N-Truncated, C-6His tag
Molecular Characterization

#N/A
Molecular Weight

48.3 KDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Formulation & Reconstitution

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage & Shipping

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Usage

Research use only
Background

Vitronectin, also known as VTN, is a large glycoprotein found in blood and the extracellular matrix (ECM). Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Images

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Figure 1. Greater than 95% as determined by reducing SDS-PAGE.