B7-H2/ICOSLG Recombinant Proteins and Flow Antibodies

B7-H2, also known as ICOS Ligand (ICOSLG), CD275, or B7RP-1, is a member of the B7 family of immune-regulatory molecules and the natural ligand of the inducible costimulatory receptor ICOS. B7-H2 is primarily expressed on antigen-presenting cells including B cells, dendritic cells, monocytes, and macrophages, while expression can also be induced on selected non-hematopoietic cells. Engagement of ICOS by B7-H2 activates signaling pathways including PI3K/AKT and promotes activated T-cell survival, proliferation, and cytokine production. The ICOS-B7-H2 pathway is particularly important for T follicular helper cell differentiation, B-cell help, humoral immunity, Th2 responses, and regulatory T-cell biology. Its context-dependent roles in immune activation, autoimmunity, and the tumor microenvironment make B7-H2 an important target for costimulatory-pathway antibodies and multispecific immune-regulatory strategies.

DIMA BIOTECH provides human and mouse B7-H2 recombinant ECD proteins in Fc/His-tagged formats for ICOS-B7-H2 interaction studies, ELISA, SPR/BLI, antibody screening, and cross-species evaluation. Multiple rabbit monoclonal antibodies validated by ELISA and flow cytometry are available together with biosimilar reference antibodies and PE- or biotin-conjugated formats. These products support cell-surface B7-H2 detection, candidate benchmarking, receptor-occupancy analysis, and development of binding or functional assays.