CLEC4C/CD303 Recombinant Proteins and Flow Antibodies

CLEC4C, also known as CD303 or BDCA-2, is a member of the C-type lectin-like receptor family. Related CLEC-family receptors include CLEC4A, CLEC4D, and CLEC4E, many of which are enriched on dendritic or myeloid-cell populations. CLEC4C is highly selective for plasmacytoid dendritic cells, specialized cells capable of producing large amounts of type I interferon after nucleic-acid sensing. Engagement and internalization of CLEC4C can modulate Toll-like receptor-associated signaling and reduce type I interferon production, making it both a useful plasmacytoid dendritic-cell marker and an attractive immune-modulatory target. CD123/IL3RA is another widely used marker of plasmacytoid dendritic cells, while IFNAR1 represents a major downstream receptor in the type I interferon pathway.

DIMA BIOTECH provides human and cynomolgus CLEC4C recombinant extracellular proteins in His- and Fc-tagged formats for ELISA, antibody screening, binding characterization, and cross-species evaluation. A flow cytometry-validated chimeric monoclonal antibody and reference antibodies are available in unconjugated, PE-conjugated, and biotinylated formats for CD303 surface detection, candidate comparison, and assay development.