CRTAM/CD355 Recombinant Proteins & Antibodies

CRTAM, or Cytotoxic and Regulatory T Cell Molecule, also known as CD355, is a type I transmembrane protein belonging to the immunoglobulin superfamily. Its expression is low on resting lymphocytes but can be rapidly induced following activation of CD8+ T cells, subsets of CD4+ T cells, and NK cells. CRTAM interacts with its ligand CADM1 and is involved in immune-cell adhesion, polarity, localization, and regulation of effector functions. It has also been linked to cytotoxic lymphocyte biology and mucosal immune responses. As interest in novel T-cell and NK-cell regulatory pathways continues to grow, CRTAM has emerged as a useful target for studying immune-cell phenotype, cell-cell interactions, and potential immune-modulatory mechanisms. Antibody discovery against CRTAM often requires careful assessment of extracellular-domain recognition, cell-surface binding, and species cross-reactivity.

DIMA BIOTECH provides human and mouse CRTAM ECD proteins, recombinant proteins covering different extracellular regions, rabbit monoclonal antibodies, biosimilar reference antibodies, and PE- or biotin-conjugated reagents. Domain proteins can be used for ELISA, antibody screening, epitope mapping, protein-interaction studies, and cross-species evaluation. Flow cytometry-validated and PE-conjugated antibodies enable cell-surface CRTAM detection and immune-cell phenotyping, while biotinylated reagents support binding and assay-development workflows.