Human / Mouse / Canine / Feline IL-31 Proteins & Antibodies

IL-31 is a member of the IL-6 cytokine family and is produced primarily by activated Th2-type T cells, although additional immune-cell populations can also contribute to its production. IL-31 signals through a heterodimeric receptor complex composed of IL31RA and OSMR and activates downstream pathways including JAK/STAT, MAPK, and PI3K/AKT. The IL-31 pathway plays an important role in communication between immune cells, sensory neurons, and skin-resident cells and has been strongly associated with pruritus, skin inflammation, and allergic disease biology. Importantly, IL-31 is relevant not only to human dermatology but also to companion-animal medicine, particularly in studies of chronic pruritus and atopic dermatitis in dogs and cats. This makes the IL-31 pathway an attractive area for veterinary therapeutic antibody development.

DIMA BIOTECH provides human, mouse, canine, and feline IL-31 recombinant proteins, including biotinylated canine and feline proteins, together with monoclonal antibodies and species-relevant reference antibodies. These multi-species reagents support ELISA, ligand-receptor interaction studies, antibody screening, affinity characterization, and cross-species reactivity evaluation. Canine and feline IL-31 products are particularly useful for companion-animal biologics programs. Through the DiLibrary™ antibody engineering platform, DIMA BIOTECH can also support canine and feline antibody engineering, affinity maturation, and functional evaluation for veterinary antibody development.