LIV-1/SLC39A6 Recombinant Proteins and Flow Antibodies

LIV-1, encoded by SLC39A6 and also known as ZIP6, is a multi-pass zinc transporter of the ZIP/SLC39 family. Other members include SLC39A4/ZIP4, SLC39A7/ZIP7, and SLC39A8/ZIP8, which regulate zinc transport and intracellular zinc homeostasis in different tissues. LIV-1 contributes to zinc influx and has been linked to transcriptional regulation, cellular adhesion, migration, and epithelial-mesenchymal transition. Initially characterized in breast biology, LIV-1 has subsequently been found to be elevated in several solid tumors and associated with invasive and metastatic behavior. Because the protein is accessible at the cell surface and can undergo antibody-mediated internalization, it is particularly relevant to antibody-drug conjugate research. Other widely investigated internalizing tumor-surface targets include HER2, TROP2, FOLR1, and Nectin-4.

DIMA BIOTECH provides recombinant human and cynomolgus LIV-1 proteins for ELISA, antibody screening, affinity characterization, and cross-species evaluation. A flow cytometry-validated chimeric monoclonal antibody is available in unconjugated, PE-conjugated, and biotinylated formats together with reference antibodies. These reagents support cell-surface LIV-1 detection, candidate comparison, and early screening before internalization and downstream functional studies.