ROR2 Recombinant Proteins, Antibodies and Stable Cell Lines

ROR2 is a receptor tyrosine kinase-like orphan receptor with extracellular immunoglobulin-like, Frizzled-like cysteine-rich, and Kringle domains. It plays important roles during embryonic development, skeletal morphogenesis, cell migration, and tissue organization and can act as a receptor or co-receptor in Wnt5a-mediated non-canonical Wnt signaling. ROR2 expression is tightly regulated in adult tissues but can be reactivated in selected solid tumors, where it has been associated with migration, invasion, tumor heterogeneity, and disease progression. Its tumor-associated cell-surface expression has generated interest in ROR2-targeting antibodies and ADC-related research.

DIMA BIOTECH provides human ROR2 full and domain-specific ECD proteins together with mouse and cynomolgus ROR2 recombinant proteins. These reagents support ELISA, antibody screening, epitope mapping, domain-recognition studies, and cross-species evaluation. ROR2 monoclonal antibodies validated for ELISA, flow cytometry, and WB are available together with reference antibodies and PE/biotin conjugates. A human ROR2-overexpressing CHO-S stable cell line enables FACS, cell-binding assays, and cell-based antibody screening and can support downstream internalization and functional evaluation.