Off-the-shelf Lead mAbs, Ready to Licensing Out

Antibody drugs are one of the most revolutionary breakthroughs in biopharmaceuticals. With their high specificity, low toxicity, and broad therapeutic potential, they have become the fastest-growing segment of the global pharmaceutical market. However, antibody drug development is a costly and time-consuming undertaking, with the preclinical development phase alone taking at least three to five years and requiring millions, if not tens of millions, of dollars in investment.

To help pharmaceutical companies accelerate the preclinical development of antibody drugs, DIMA BIOTECH has launched the “All Druggable Targets” lead antibody molecule development program, leveraging its proprietary, innovative single B cell development platform. DIMA BIOTECH will generate lead antibody molecules and corresponding B cell seed libraries targeting all druggable targets. Clients can directly import lead antibody molecules from DIMA BIOTECH or rapidly screen for additional lead antibodies from the B cell seed library. Compared to traditional hybridoma technology, DIMA BIOTECH can save clients up to nearly a year in development time.

To date, DIMA BIOTECH has screened over 5,000 lead antibody sequences, covering over 500 druggable targets. All of these have been sequenced and are available for global licensing. For some popular target sequences, DIMA BIOTECH has also conducted human-monkey cross-talk and in vitro functional validation. Clients can immediately import sequences and data packages for functional validation, enabling them to be one step ahead and seize market opportunities.

DIMA's Features

Off-the-Shelf Lead mAbs

  • No Upfront: Pay after testing
  • No Waiting: Same-day delivery
  • No risk: No payment if validation is invalid
  • High quality: All antibodies are FC-validated
  • High efficiency: Save at least 8 months of R&D time

B Cell Seed library

  • No risk: No payment if validation is invalid
  • Diversity: Multiple FACS binders
  • High quality: Serum-free polyclonal Ab identification and FACS functional validation
  • High efficiency: Save at least 6 months of R&D time

Partial Popular Targets

Click to view all the leads from DIMA BIOTECH

Case Study

Animal survival data summary on selected CAR constructs

93 days post CAR T-cells infusion, red box-labelled groups of mice are still alive. 

GPRC5D G07 membrane protein array (MPA)

DIMA's GPCR CAR-T candidate has entered clinical, please click to view the clinical data

DIMA’s GPRC5D x CD3 BsAb format (KIH) 

DIMA utilizes Fab-ScFV-IgG1(KIH) format CD3 :SP34 

BsAb(GPRC5D X CD3) affinity ranking by flow assay

G05, 07 and 09 are DIMA’s BsAb; Talquetamab is J&J’s BsAb; G00 is the BsAb derived from scFv of Eureka and BMS’s MCARH109

In Vitro tumor cell (8226-GFP-LUC) killing assays with BsAbs

T cells and tumor cells were mixed at 3:1 ratio and different concentration of BsAbs were added and further incubated for 48hrs before assay analysis.

Cyno and mouse cross-reactivity tests 

Clones cross-react with Cyno GPRC5D: G00, G05, G07, G09
Clone cross-react with mouse GPRC5D: G00

Clone G05 exhibits strong internalization property 

Clone G05 exhibits strong internalization property

Development of anti-BCMA therapeutic mAbs for CAR-T application

Lead mAbs Service