| Target | |
|---|---|
| Synonyms | BAFFR,TNFRSF13C,BAFF-R,BROMIX,CD268,CVID4,prolixin |
| Host Species | Rabbit |
| IgG type | Rabbit IgG |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | ELISA, Flow Cyt |
| Recommended Dilutions | ELISA 1/5000-10000;Flow Cyt 1/100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Buffer | 1XPBS |
| Formulation & Reconstitution | Liquid |
| Delivery | In Stock |
| Usage | Research use only |
| Background | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. |
Anti-BAFF-R antibody(DM143), Rabbit mAb
Price: 10μg $99.00 ; 100 μg $438.00 ; 500 μg $1314.00
Product Data
Images
Figure 1. ELISA plate pre-coated by 1 μg/ml (100 μl/well) Human BAFFR protein, mFc tagged protein (PME100044) can bind Rabbit anti-BAFFR monoclonal antibody(clone: DM143) in a linear range of 0.8-50
Figure 2. Flow cytometry analysis with Anti-BAFFR (DM143) on Expi293 cells transfected with human BAFFR (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).