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Human ADAM17 Protein, hFc Tag

Price: 10μg $69.00 ; 50μg $274.00 ; 100 μg $411.00

SKU: PME101098 Category:
Product Data
Target

Synonyms

ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
Description

Recombinant human ADAM17 protein with C-terminal human Fc tag
Delivery

Under development
Uniprot ID

P78536
Expression Host

HEK293
Tag

C-Human Fc
Molecular Characterization

ADAM17 (Lys215-Asn671)+hFc(GLU99-ALA330)
Molecular Weight

The protein has a predicted molecular mass of 75.79 kDa after removal of the signal peptide.
Purity

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution

Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage & Shipping

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
Usage

Research use only
Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
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