SEZ6 recombinant proteins and antibodies

Epilepsy-associated homologue 6 (SEZ6) is a transmembrane protein found on the cell surface of cells of selected neuronal lineages. SEZ6, together with epilepsy-associated 6-like protein (SEZ6L) and epilepsy-associated 6-like protein 2 (SEZ6L2), form the SEZ6 family. EZ6 is mainly expressed in neurons, with the highest expression in the embryonic and postnatal neocortex. In the adult mouse brain, SEZ6 expression is reduced, but it can still be detected in the middle cortical layer, olfactory duct, cingulate cortex, and hippocampus (mainly in CA1). SEZ6 is involved in neural dendrite formation, and regulates neural signal transmission, which is closely related to the progression of neuroendocrine tumors (NETs). More about SEZ6 function >>

In addition, because SEZ6 is selectively highly expressed on neuroendocrine tumor cells, but is rarely expressed in most normal tissues, this differential expression makes it a potential drug target for NETs.

To accelerate the development of SEZ6 biotherapy, DIMA BIOTECH has produced a full range of products targeting SEZ6, including active proteins, flow cytometry-validated monoclonal antibodies, and stably transfected cell lines. It can also provide customized services for multiple genus protein antibodies targeting SZE6, antibody humanization, and affinity maturation services. In addition, DIMA BIOTECH has also prepared a single B cell seed bank targeting SEZ6, and lead antibody molecules can be obtained in as fast as 28 days. At the same time, we have currently screened dozens of SEZ6 lead molecules, and customers can get the molecules for functional evaluation and verification the next day. For some molecules, we are also conducting ADC endocytosis activity and killing verification, and please feel free to inquire for specific data.