OX40 Ligand/TNFSF4 Recombinant Proteins and Flow Antibodies

OX40 Ligand, encoded by TNFSF4 and also known as OX40L, CD252, or CD134L, is a member of the TNF ligand superfamily. Other immune-regulatory members include 4-1BBL/TNFSF9, CD40L/TNFSF5, CD70/TNFSF7, GITRL/TNFSF18, and BAFF/TNFSF13B. OX40L is the natural ligand of the costimulatory receptor OX40/TNFRSF4/CD134 and is induced primarily on activated dendritic cells, B cells, macrophages, and selected other cell types. OX40 engagement enhances T-cell proliferation, survival, cytokine production, and memory formation and can influence the balance between effector and regulatory T-cell responses. The OX40-OX40L pathway therefore belongs to a broader TNF-superfamily costimulatory network that also includes 4-1BB/4-1BBL, CD40/CD40L, and GITR/GITRL.

DIMA BIOTECH provides human and mouse OX40 Ligand recombinant proteins in human Fc-, mouse Fc-, His-, and biotinylated formats for OX40-OX40L interaction studies, ELISA, SPR/BLI, antibody screening, and cross-species evaluation. A rabbit monoclonal antibody validated by ELISA and flow cytometry is available together with PE- and biotin-conjugated versions and reference antibodies.