three types of DIMA BIOTECH Full-length Membrane Protein Nanodisc-2

Nanodisc-based Full-Length Membrane Proteins

700+ Targets · 350+ In Stock · HEK293 Expressed

· Biotinylated Formats Available

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Types of Nanodisc-Based Membrane Proteins

Nanodiscs can be classified based on the stabilizing agents used. The major formats are MSP Nanodiscs, Synthetic Nanodiscs, and PeptiNanodiscs. To fully leverage Nanodiscs, DIMA BIOTECH uses the HEK293 system to produce recombinant membrane proteins (MPs) that closely mimic their natural forms, supporting faster and more reliable drug discovery. Currently, DIMA BIOTECH has rich experience in developing full-length multi-pass membrane proteins with Synthetic Nanodiscs and PeptiNanodiscs.

ploymer-nanodisc

Synthetic Nanodisc Membrane Proteins

Polymer-based full-length membrane proteins for GPCR, ion channel and transporter studies, including ELISA, SPR and antibody-binding assays.

All Synthetic Nanodisc MPs
peptide-based nanodisc

PeptiNanodisc Membrane Proteins

Peptide-based full-length membrane proteins optimized for flow cytometry, CAR-T detection and antibody screening.

All PeptiNanodisc MPs

Validation Data of Nanodisc-based Membrane Proteins

The purity of Human SLC7A11-Nanodisc (FLP100048) is greater than 90% as determined by SEC-HPLC.

Human GPR75-synthetic nanodisc (FLP120031) can bind Loaded Human GPR75 mAb (DMC100368) with an affinity constant of 5.02nM.

Human CLDN18.2-synthetic nanodisc (FLP120014) can bind loaded Human CLDN18.2 mAb (BME100075) with an affinity constant of 8.09nM.

GPRC5D PeptiNanodisc (Cat.No.FLP400011) and G4S-PE protein were used to detect the positivity rate of GPRC5D CAR-T cells.

nanodisc immunity

Why Choose Us?

  • Extensive portfolios of Synthetic Nanodisc and PeptiNanodisc proteins
  • HEK293-expressed full-length membrane proteins with multiple tag and biotinylated options
  • Batch-level quality and functional validation for research applications
  • In-stock products, custom target development and technical support

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Nanodisc Technology

What are Nanodiscs?

Nanodiscs provide a membrane-like environment that stabilizes membrane proteins (MPs) in a near-native state, overcoming major challenges in MP expression, purification, and functional analysis. Full-length multi-pass membrane proteins are often difficult to express, prone to misfolding, and easily destabilized by traditional detergents. By improving protein stability, activity, and structural integrity, Nanodiscs enable more reliable structural studies, functional assays, and drug screening. Platforms such as MSP, Synthetic, and PeptiNanodiscs further support diverse membrane protein research and accelerate drug discovery.

Why Nanodiscs for Membrane Proteins?

Nanodiscs are discoidal lipid bilayers stabilized by scaffold proteins or synthetic polymers. They maintain:

  • Native folding of GPCRs, ion channels, transporters, and multi-pass receptors
  • High monodispersity suitable for cryo-EM and NMR
  • Improved solubility and stability without detergents
  • Reliable performance in binding, functional, and biophysical assays
  • Enhanced batch consistency, critical for drug screening workflows
Explore more information of the application of nanodisc in membrane protein

Nanodisc Protein Products

Explore all synthetic nanodisc protein
Explore all peptinanodisc proteins
the structure of GPCRs

G protein-coupled receptors (GPCRs)

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the structure of ion channel-1-1

Ion Channels

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FAQs

1. Which materials are used for Nanodisc Proteins?

We utilize synthetic nanodiscs that are internally synthesized within our company. However, specific details regarding the composition of our nanodiscs are proprietary and confidential.

2. Is it possible to purchase empty nanodiscs?

Currently, we do not have empty nanodiscs available for purchase. However, we do offer nanodiscs designed for specific target proteins.

3. Has the function of the protein/nanodisc been tested after lyophilization and dissolving?

Yes, all our nanodiscs undergo comprehensive lyophilization and testing procedures. The data presented on our website is derived from the protein after the lyophilization and reconstitution process. The products are shipped at room temperature after lyophilization.

 

Explore all the FAQs of Nanodisc-based proteins

Citation

  1. Li J, Zhou Z, Wu Y, et al. Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons. Theranostics. 2025 Jan 1;15(4):1376-1398. Product from DIMA BIOTECH: Human TRPV1 full length protein-synthetic nanodisc (FLP100128)
  2. Muratspahić E, Feldman D, Kim DE, et al. De novo design of miniproteins targeting GPCRs. Nature. 2026 May 21. Product from DIMA BIOTECH: Human CXCR4 full length protein-synthetic nanodisc (FLP100074); Human OXYR full length protein-synthetic nanodisc (FLP100429)
  3. Li, M., Lai, L. circ-E2F3 drives ovarian cancer progression via the miR-1305/STAT3 axis through modulation of ferroptosis. Sci Rep (2026). Product from DIMA BIOTECH: Human SLC7A11 full length protein-synthetic nanodisc (FLP100048)

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