As one of the most important membrane protein families, G protein–coupled receptors (GPCRs) are notoriously difficult to analyze due to their complex conformations and membrane-embedded nature.

DIMA Biotech’s live-cell flow cytometry antibodies are specially optimized to recognize native extracellular epitopes of GPCRs without permeabilization, enabling accurate surface detection and quantitative analysis in living cells.
This innovation allows researchers to observe receptor dynamics in their native conformations, revealing the true biological activity of GPCRs.

The structural complexity behind the world’s largest receptor family

• 🧩 Seven transmembrane domains — only small extracellular loops are accessible for antibody binding.

• 💧 Permeabilization-dependent assays — often destroy the receptor’s native structure.

• 📉 Low signal-to-noise ratio — hinders accurate quantification and live-cell applications.

These challenges make it difficult to study GPCRs in their true, functional state.

GPCRs are complex seven-transmembrane proteins whose native conformations are difficult to preserve with traditional antibodies, which often require permeabilization and can disrupt membranes, cause signal loss, or introduce false positives. DIMA’s GPCR flow cytometry antibodies overcome these limitations by using native-conformation antigens generated through our DiMPro^TM Nanodisc platform. These antibodies specifically recognize GPCR epitopes on the surface of live cells, enabling direct detection without permeabilization. This approach allows researchers to measure GPCR expression and conformational changes under conditions that closely reflect physiological states, providing more reliable, accurate, and biologically meaningful data for GPCR research and drug development.

Key advantages:

DIMA offers an extensive library of GPCR flow cytometry antibodies, covering multiple research areas including immunology, neuroscience, metabolism, and oncology:

…More GPCR targets are continuously being added.

Powered by our DiMPro^TM Nanodisc , DIMA is steadily expanding its portfolio of GPCR flow cytometry antibodies that recognize native conformations. These tools enable researchers to perform high-specificity live-cell detection and quantitative analysis with ease, providing comprehensive support for GPCR drug discovery.

Our GPCR antibodies are carefully developed and validated to target native extracellular epitopes, ensuring high specificity in live-cell flow assays.

Anti-CCR1 antibody(DMC465); IgG1 Chimeric mAb

Anti-CCR6 antibody(DMC477); IgG1 Chimeric mAb

Anti-GPRC5D antibody(DM91); Rabbit mAb