| Target | |
|---|---|
| Synonyms | 5-HT6; 5-HT6R |
| Description | Recombinant human HTR6 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P50406 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | HTR6(Met1-Gly27) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 28.6 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | HTR6 encodes the 5-hydroxytryptamine (serotonin) receptor 6, a G-protein coupled receptor (GPCR) that primarily couples to Gs proteins, leading to activation of adenylyl cyclase and elevation of intracellular cAMP levels. It is mainly expressed in the central nervous system, particularly in the striatum, cortex, hippocampus, and olfactory tubercle, where it modulates cholinergic, dopaminergic, and glutamatergic neurotransmission. HTR6 plays important roles in cognition, learning, memory, and mood regulation. Dysregulation of HTR6 signaling has been implicated in Alzheimer’s disease, schizophrenia, and cognitive impairment, making it a potential therapeutic target for neuropsychiatric and neurodegenerative disorders. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human HTR6 Protein, hFc Tag
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. Human HTR6 Protein, hFc Tag on SDS-PAGE under reducing condition.
Related Products
ECD Proteins
SKU: PME100002 Target: CS1 Tag: C-Human Fc and 6×His Tag
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100012 Target: B7-H3 Tag: C-Mouse Fc and 6×His Tag
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100013 Target: CD27 Tag: C-Mouse Fc and 6×His Tag
Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00
ECD Proteins
SKU: PME100009 Target: SIRPa Tag: C-Human Fc and 6×His Tag
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100667 Target: GFAP Tag: N-6×His Tag
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100007 Target: FLT3 Tag: C-Human Fc and 6×His Tag
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100655 Target: FOLR2 Tag: C-6×His Tag
Price:10μg $81.00 ; 50μg $170.00 ; 100μg $234.00
ECD Proteins
SKU: PME100003 Target: CD123 Tag: C-Human Fc and 6×His Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100072 Target: ACE2 Tag: C-Mouse Fc Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00