Human IL2RB-knob and IL2RG-Hole Heterodimer Protein, His Tag and Strep tag

Name: Human IL2RB-knob and IL2RG-Hole Heterodimer Protein, His Tag and Strep tag - DIMA Biotechnology
SKU: PME101985
Price: 1095005033000100480.00 USD
Availability: InStock

Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00

SKU: PME101985 Category: ECD Proteins

Datasheet

MSDS

Each batch undergoes strict quality control and contact us to know the details.

Product Data Dima FAQ

Target	IL2RB and IL2RG
Synonyms	IL-2 R beta & IL-2 R gamma,IL-2RB & IL-2RG
Description	Recombinant human IL2RB-knob protein with C-terminal 6×His tag and human IL2RG-Hole protein with C-terminal Strep tag
Delivery	In STOCK
Uniprot ID	P14784 and P31785
Expression Host	HEK293
Tag	C-6×His tag and C-Strep tag
Molecular Characterization	IL2RB(Ala27-Asp239) knob 6×His tag IL2RG(Leu23-Asn254) Hole Strep tag
Molecular Weight	The protein has a predicted molecular mass of 52.0 kDa and 56.7 kDa after removal of the signal peptide.
Purity	The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Sterility	Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use.
Storage&Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
Background	The IL2RB and IL2RG heterodimer is composed of interleukin-2 receptor subunit beta (IL2RB/CD122) and the common gamma-chain receptor subunit (IL2RG/CD132). Together, these subunits form the intermediate-affinity interleukin-2 receptor and constitute the signaling components of the high-affinity IL-2 receptor complex when associated with IL2RA/CD25. IL2RB and IL2RG are also essential components of the interleukin-15 receptor complex. Upon ligand-induced receptor assembly, IL2RB and IL2RG activate JAK1 and JAK3, leading to downstream signaling through the STAT5, PI3K–AKT, and MAPK pathways. These signaling pathways regulate the proliferation, survival, differentiation, and effector functions of T cells, natural killer cells, and other immune cells. Dysregulation of IL-2 and IL-15 receptor signaling is associated with autoimmune diseases, immunodeficiency, inflammation, and cancer. Recombinant IL2RB and IL2RG heterodimer protein is suitable for cytokine–receptor interaction studies, binding and functional assays, antibody screening, drug discovery, and the development of IL-2- or IL-15-based therapeutics.
Usage	Research use only
Conjugate	Unconjugated