Human ACE2 Protein, mFc Tag
|Package||10 μg $70.00; 50 μg $280.00;100 μg $380.00|
|Description||Recombinant human ACE2 protein with C-terminal mouse Fc tag|
|Tag||C-Mouse Fc tag|
|Molecular Weight||The protein has a predicted molecular mass of 109.7 kDa after removal of the signal peptide.|
|Purity||The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.|
|Formulation & Reconstitution||Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.|
|Storage||Store at -20°C to -70°C for 12 months in lyophilized state|
|Usage||Research use only|
Figure 1. Human ACE2 Protein, mFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) S-RBD, hFc tagged protein (PME100487) can bind Human ACE2, mFc Tagged protein (PME100072) in a linear range of 0.976-39.35 ng/ml.
|Background||The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.|