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Human BCMA Protein, hFc-His Tag

Product Overview
Catalog Number PME100001
Package 10 μg $60.00 ; 50 μg $265.00 ; 100 μg $378.00
Description Recombinant human BCMA protein with C-terminal human Fc and 6×His tag
Synonyms TNFRSF17, CD269, BCM, BCMA
Delivery
Uniprot ID
Expression Host HEK293
Tag C-Human Fc and 6×His tag
Molecular Characterization
Molecular Weight The protein has a predicted molecular mass of 32.7 kDa after removal of the signal peptide. The apparent molecular mass of BCMA-hFc-His is approximately 40 kDa due to glycosylation.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Storage Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only
Images

Figure 1. Human BCMA, hFc-His Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human BCMA, hFc-His tagged protein can bind Anti-BCMA (Neutralizing antibody clone huC11D5.3) (BME100016) in a linear range of 3.71-22.29 ng/ml.

Background B-cell maturation protein (BCMA or BCM), is also known as Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), which is encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).This receptor is expressed in immune organs and mature B cell lines. BCMA promotes B-cell survival and plays a role in the regulation of humoral immunity. BCMA can activate NF-kappa-B and JNK.
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