products-dme

Biotinylated Anti-CS1 antibody(DM9); Rabbit mAb

Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00

SKU: DME100009B Category:
Datasheet
MSDS
Product Data
Target

Synonyms

SLAM7 (19A; CD319; CRACC; CS1)
Host Species

Rabbit
Description

Biotinylated Anti-CS1 antibody(DM9); Rabbit mAb
Delivery

2-3 weeks
Uniprot ID

Q9NQ25
IgG type

Rabbit IgG
Clonality

Monoclonal
Reactivity

Human
Applications

ELISA; Flow Cyt
Recommended Dilutions

Flow Cyt 1:100
Purification

Purified from cell culture supernatant by affinity chromatography
Formulation & Reconstitution

Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins; SH2D1A:SAP and:or SH2D1B:EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1; PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However; in the absence of SH2D1B; inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Usage

Research use only
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