| Target | |
|---|---|
| Synonyms | CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 |
| Description | Recombinant Canine PD-1 protein with C-terminal mouse Fc Avi tag |
| Delivery | In STOCK |
| Uniprot ID | NP_001301026.1 |
| Expression Host | HEK293 |
| Tag | C-Mouse Fc Avi tag |
| Molecular Characterization | PD-1(Leu25-Gly168)+mFc(Pro99-Lys330)+Avi tag |
| Molecular Weight | The protein has a predicted molecular mass of 44.2 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] |
| Usage | Research use only |
| Conjugate | Biotinylated |
Biotinylated Canine PD-1 Protein, mFc Tag
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. Biotinylated Canine PD-1 Protein, mFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Anti-Canine PD-1(INTERVET 4F12) mAb (BME100202) can bind Biotinylated Canine PD-1 Protein, mFc Tag (PME-D100006B) in a linear range of 8–40 ng/mL. In order to specifically detect PME-D100006B, HRP Conjugated-Streptavidin was used as detection antibody.
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