IL18BP, IL18BPa, Tadekinig-alfa
Recombinant Cynomolgus IL18BP protein with C-terminal 6×His tag
The protein has a predicted molecular mass of 20.1 kDa after removal of the signal peptide.
The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
|Formulation & Reconstitution||
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
|Storage & Shipping||
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).lyophilized proteins are shipped at ambient temperature.
10 μg $250.00 ; 50 μg $938.00 ; 100 μg $1375.00
Research use only
Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
Cynomolgus IL18BP Protein, His Tag
Price: 10 μg $250.00 ; 50 μg $938.00 ; 100 μg $1375.00
SKU: PME-C100015 Category: ECD Proteins
Figure 1. Cynomolgus IL18BP Protein, His Tag on SDS-PAGE under reducing condition.