| Target | |
|---|---|
| Synonyms | AMDM;ANPb;NPR2;ECDM;GC-B;GCB;GUC2B;GUCY2B;NPRB;NPRBi;SNSK |
| Description | Recombinant Human ANPRB Protein with C-terminal 6×His tag |
| Delivery | In Stock |
| Uniprot ID | P20594 |
| Expression Host | HEK293 |
| Tag | C-6×His Tag |
| Molecular Characterization | ANPRB(Arg23-Ile458) 6×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 49.3 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human ANPRB Protein, His Tag
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. Human ANPRB Protein, His Tag on SDS-PAGE under reducing condition.
Cited in Literature
Hirai K, Sawamura K, Esaki R, Sawada R, Okusha Y, Aoyama E, Saito H, Uchida K, Mima T, Kubota S, Tsukahara H, Imagama S, Matsushita M, Matsushita O, Hosono Y. Collagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis. JCI Insight. 2025 Dec 23;11(3):e198959. (PubMed)
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