IL-23; IL-23A; IL23P19; P19; SGRF & CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2
IL23A（Arg20-Pro189）+hFc（Glu99-Ala330）& IL12B（Ile23-Ser328）+6×His tag
Recombinant human IL23A protein with C-terminal human Fc tag & human IL12B protein with C-terminal 6×His tag
The protein has a predicted molecular mass of 44.8 & 35.5 kDa after removal of the signal peptide. The apparent molecular mass of IL23A-hFc & IL12B-His is approximately 35-55 kDa due to glycosylation.
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
|Formulation & Reconstitution||
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
|Storage & Shipping||
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
Research use only
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Human IL23A & IL12B Heterodimer Protein, hFc Tag & His Tag
Price: 10μg $67.00 ; 50μg $244.00 ; 100μg $367.00
SKU: PME101238 Category: ECD Proteins
Figure 1.Human IL23A & IL12B Heterodimer Protein, hFc Tag & His Tag on SDS-PAGE under reducing condition.