| Target | |
|---|---|
| Synonyms | GP130, CD130, IL6Rβ, IL6 receptor subunit beta, IL6 signal transducer |
| Description | Recombinant human IL6ST Protein with C-terminal 10×His tag |
| Delivery | In Stock |
| Uniprot ID | P40189 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | IL6ST(Glu23-Glu619) 10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 69.2 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | IL6ST (GP130 / Interleukin-6 signal transducer) is a transmembrane receptor subunit that mediates signaling of the IL-6 family cytokines, including IL-6, IL-11, LIF, and OSM. It forms heterodimeric or multimeric receptor complexes, activating JAK/STAT, MAPK, and PI3K/AKT pathways. IL6ST is widely expressed in immune cells, liver, heart, and other tissues, regulating inflammation, hematopoiesis, immune responses, and tissue regeneration. Dysregulation is associated with autoimmune diseases, chronic inflammation, and cancer, making it an important therapeutic target in cytokine-mediated disorders. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human IL6ST Protein, His Tag
Price:10μg $95.00 ; 50μg $330.00 ; 100μg $500.00
Product Data Dima FAQ
Images Dima FAQ
Figure 1. Human IL6ST Protein, His Tag on SDS-PAGE under reducing condition.
Related Products
ECD Proteins
SKU: PME100010 Target: 2B4 Tag: C-Mouse Fc and 6×His Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100671 Target: RSPO3 Tag: C-Human Fc Tag
Price: 10μg $72.00; 50μg $274.00 ; 100 μg $411.00
ECD Proteins
SKU: PME100036 Target: S protein RBD Tag: C-6×His Tag
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME100657 Target: Nucleocapsid Tag: C-6×His Tag
Price: 10μg $72.00; 50μg $272.00; 100μg $409.00
ECD Proteins
SKU: PME100020 Target: GITR Ligand Tag: N-Mouse Fc and C-6×His Tag
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME100005 Target: CD22 Tag: C-Human Fc and 6×His Tag
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
ECD Proteins
SKU: PME100072 Target: ACE2 Tag: C-Mouse Fc Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
ECD Proteins
SKU: PME100655 Target: FOLR2 Tag: C-6×His Tag
Price:10μg $81.00 ; 50μg $170.00 ; 100μg $234.00
ECD Proteins
SKU: PME100003 Target: CD123 Tag: C-Human Fc and 6×His Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00