| Target | |
|---|---|
| Synonyms | Brain-Derived Neurotrophic Factor;BDNF;Abrineurin |
| Description | Recombinant Human Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding His129-Arg247 is expressed. |
| Delivery | In Stock |
| Uniprot ID | P23560 |
| Expression Host | E.coli |
| Tag | |
| Molecular Characterization | Not available |
| Molecular Weight | 13 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation & Reconstitution | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. |
| Usage | Research use only |
Human/Murine/Rat BDNF Protein
Price: 50 μg $503.00
Product Data
Images
Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
Figure 2. Immobilized Human TrkB-His at 2ug/ml (100 μl/well) can bind Human BDNF*: Biotinylated by NHS-biotin prior to testing. The ED50 of Human BDNF* is 47.58 ng/ml.