| Target | |
|---|---|
| Synonyms | NPC1-like intracellular cholesterol transporter 1;Niemann-Pick C1-like protein 1 |
| Description | Recombinant human NPC1L1 protein with C-terminal 6×His tag |
| Delivery | In Stock |
| Uniprot ID | Q9UHC9 |
| Expression Host | HEK293 |
| Tag | C-6×His Tag |
| Molecular Characterization | NPC1L1(Glu22-Ser284) 6×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 28.8 kDa after removal of the signal peptide. The apparent molecular mass of NPC1L1-His is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human NPC1L1 Protein, His Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
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Figure 1. Human NPC1L1 Protein, His Tag on SDS-PAGE under reducing condition.
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