| Synonyms | ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3 |
|---|---|
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Target | |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Uniprot ID | P24158 |
| Description | Recombinant Human PRTN3 Protein with C-terminal 6×His tag |
| Molecular Characterization | PRTN3（Ala26-Pro256）+6×His tag |
| Expression Host | HEK293 |
| Delivery | In Stock |
| Molecular Weight | The protein has a predicted molecular mass of 26.2 kDa after removal of the signal peptide. The apparent molecular mass of PRTN3-His is approximately 25-35 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Usage | Research use only |
| Background | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).[UniProtKB/Swiss-Prot Function] |
Human PRTN3 Protein, His Tag
Price: 10μg $125.00 ; 50μg $469.00 ; 100 μg $688.00
Product Data
Images
Figure 1. Human PRTN3 Protein, His Tag on SDS-PAGE under reducing condition.