EPCAM/CD326 Recombinant Proteins, Antibodies and Stable Cell Lines

Epithelial Cell Adhesion Molecule (EPCAM), also known as TACSTD1 or CD326, is a type I transmembrane glycoprotein broadly expressed by epithelial cells. Initially characterized primarily as a cell-adhesion molecule, EPCAM is now known to participate in signaling networks related to proliferation, differentiation, stem-like phenotypes, and epithelial organization. Regulated proteolytic processing can release an intracellular EPCAM domain involved in transcriptional signaling. EPCAM is frequently upregulated across epithelial malignancies and is widely used for identification and enrichment of circulating tumor cells. Its high cell-surface density has also made EPCAM an established target for monoclonal antibodies, ADCs, T-cell engagers, multispecific antibodies, and engineered cell therapies.

DIMA BIOTECH provides recombinant human EPCAM ECD proteins for ELISA, antibody screening, affinity characterization, and epitope studies. Flow cytometry-validated rabbit monoclonal antibodies, multiple reference antibodies, and PE/biotin-conjugated formats support cell-surface EPCAM detection and candidate benchmarking. An EPCAM-overexpressing Jurkat stable cell line provides a standardized platform for FACS, cell-binding assays, and cell-based candidate screening. These products support EPCAM antibody programs from initial protein binding through native cell-surface evaluation.