FAP Recombinant Proteins, Reference Antibodies and Stable Cell Lines

Fibroblast Activation Protein (FAP), also known as FAPα, is a type II transmembrane serine protease that is expressed at relatively low levels in most healthy adult tissues but is strongly induced during tissue remodeling, fibrosis, wound healing, and cancer. Within tumors, FAP is widely used as a marker of cancer-associated fibroblasts (CAFs). FAP-positive stromal cells can influence extracellular-matrix remodeling, angiogenesis, cytokine signaling, immune-cell infiltration, and tumor progression. These characteristics have expanded interest in FAP beyond fibroblast biology into tumor-microenvironment targeting, molecular imaging, targeted delivery, and cell-based therapeutic research.

DIMA BIOTECH provides human, cynomolgus, and mouse FAP recombinant ECD proteins in multiple formats, including His- and Fc-tagged constructs. These proteins support ELISA, protein-interaction analysis, antibody screening, affinity characterization, and cross-species reactivity studies. A flow cytometry-validated FAP reference antibody can be used for cell-surface binding and candidate benchmarking. In addition, a human FAP-overexpressing K562 stable cell line provides a standardized platform for FACS, cell-binding assays, and cell-based antibody screening. The combined protein, antibody, and cellular toolkit can support progression from biochemical binding studies to cellular evaluation of FAP-targeting molecules.