FCRL5/CD307e Proteins, Antibodies & Cell Lines

FCRL5, also known as CD307e or FCRH5, is a type I transmembrane member of the Fc receptor-like protein family. Its extracellular region contains multiple immunoglobulin-like domains, while its expression is primarily associated with the B-cell lineage. FCRL5 is found on subsets of mature B cells and plasma cells and is also expressed in selected B-cell and plasma-cell malignancies. These characteristics have driven increasing interest in FCRL5 as a target for monoclonal antibodies, bispecific antibodies, and other multispecific therapeutic formats. Because FCRL5 has a long and structurally complex extracellular region, antibodies recognizing different Ig-like domains may display distinct binding characteristics and may influence the design and geometry of downstream therapeutic molecules.

DIMA BIOTECH provides human, cynomolgus, and mouse FCRL5 recombinant proteins, multiple proteins covering distinct extracellular Ig-like regions, biotinylated proteins, flow cytometry antibodies, biosimilar reference antibodies, PE/biotin-conjugated reagents, and an FCRL5-overexpressing K562-Luc stable cell line. Domain-specific proteins are particularly useful for antibody screening and epitope mapping, while proteins from multiple species support cross-reactivity assessment. The stable cell line and flow antibodies can be used for FACS, cell-binding assays, and cell-based candidate screening. These tools can also support subsequent development and evaluation of multispecific antibody formats.