FGFR2b/FGFR2c Recombinant Proteins, Domain ECDs and Reference Antibodies

Fibroblast Growth Factor Receptor 2 (FGFR2) is a receptor tyrosine kinase composed of extracellular immunoglobulin-like domains, a single transmembrane segment, and an intracellular kinase domain. FGF ligands bind FGFR2 together with heparin or heparan sulfate, inducing receptor dimerization and activation of RAS/MAPK, PI3K/AKT, PLCγ, and STAT signaling pathways. FGFR2 plays essential roles in development, proliferation, differentiation, migration, and epithelial-mesenchymal communication. A defining feature of FGFR2 biology is alternative splicing of the third immunoglobulin-like domain, generating FGFR2b/IIIb and FGFR2c/IIIc isoforms. FGFR2b is predominantly epithelial, whereas FGFR2c is associated more strongly with mesenchymal cells, and the two isoforms display distinct ligand specificity. FGFR2 amplification, mutation, fusion, or abnormal expression can contribute to developmental disorders and multiple cancers.

Currently, DIMA BIOTECH supplies human FGFR2b and FGFR2c recombinant proteins together with domain proteins covering residues 313–363 in hFc- and mFc-tagged formats. These reagents support ligand-binding studies, ELISA, antibody screening, domain recognition, epitope mapping, and evaluation of FGFR2b versus FGFR2c selectivity. A biosimilar reference antibody is also available for ELISA, candidate benchmarking, and assay development. Because antibody activity against FGFR2 can depend strongly on isoform and epitope selection.