IL31RA Recombinant Proteins, Antibodies and Canine/Feline Research Tools

IL31RA is the receptor-alpha subunit of the IL-31 signaling complex and forms a functional heterodimer with OSMR. Binding of IL-31 activates downstream pathways including JAK/STAT, MAPK, and PI3K/AKT and contributes to communication among sensory neurons, keratinocytes, and immune cells. The IL-31/IL31RA pathway is strongly associated with pruritus, cutaneous inflammation, and allergic immune responses. Importantly, this pathway is highly relevant not only to human inflammatory skin biology but also to chronic pruritus and allergic skin disease in dogs and cats, making IL31RA a valuable target for companion-animal antibody research.

DIMA BIOTECH provides full and domain-specific human IL31RA recombinant proteins in His-, hFc-, and mFc-tagged formats, together with canine and feline IL31RA proteins. These reagents support IL-31 receptor interaction studies, ELISA, antibody screening, domain-recognition analysis, and cross-species evaluation. Monoclonal antibodies, biosimilar reference antibodies, and PE- or biotin-conjugated formats can be used for flow cytometry, receptor detection, candidate benchmarking, and assay development. Combined with DIMA BIOTECH’s canine/feline antibody engineering capabilities, these products can further support species-specific antibody optimization and functional validation for companion-animal biologics.