APP Recombinant Proteins, Antibodies and Neurodegeneration Research Tools

Amyloid precursor protein (APP) is a widely expressed type I transmembrane protein with particular importance in neuronal biology. Sequential processing by α-, β-, and γ-secretases generates soluble APP fragments, intracellular domains, and amyloid-β peptides. Non-amyloidogenic processing avoids Aβ formation, whereas β/γ-secretase-dependent processing can generate aggregation-prone Aβ species whose accumulation is a major focus of Alzheimer’s disease research. APP also participates in neuronal development, synaptic biology, axonal transport, and cellular adhesion. Antibody programs therefore need to distinguish whether a candidate recognizes full-length APP, a soluble cleavage fragment, a specific Aβ sequence, or a disease-associated conformation.

DIMA BIOTECH provides recombinant human APP protein for ELISA, antibody screening, and APP-related binding studies. The portfolio also includes monoclonal and reference antibodies, including flow-cytometry, PE-conjugated, and biotinylated formats, for candidate benchmarking, cellular APP detection, capture assays, and neurodegeneration-related assay development. When designing APP/Aβ experiments, defining the intended antigenic form and epitope is particularly important for selecting appropriate reagents and interpreting binding data.