CD22/SIGLEC2 Recombinant Proteins and Flow Antibodies

CD22, also known as SIGLEC2, is a B-cell-restricted type I transmembrane member of the Siglec family with multiple extracellular immunoglobulin-like domains that recognize sialylated glycans. Its intracellular region contains ITIM motifs that recruit phosphatases such as SHP-1, providing negative feedback to B-cell receptor signaling and helping maintain B-cell activation thresholds and immune tolerance. CD22 remains highly expressed in multiple B-cell malignancies and undergoes efficient antibody-mediated internalization, making it an important target for antibodies, ADCs, multispecific molecules, and engineered cell therapies.

DIMA BIOTECH provides multiple recombinant CD22 ECD proteins in different formats for ELISA, antibody screening, epitope mapping, binding characterization, and cross-species assessment. Flow cytometry-validated monoclonal antibodies and reference antibodies, including PE- and biotin-conjugated formats, support B-cell surface detection, candidate benchmarking, and assay development. These reagents can also be integrated with downstream cell-binding, internalization, and functional assays to evaluate CD22-targeting candidates from protein-level binding through cellular validation.