CD24 Full-Length Membrane Proteins, ECDs and Flow Antibodies

Signal transducer CD24 (CD24) is a small, highly glycosylated GPI-anchored cell-surface protein with developmentally regulated expression on B-cell populations, hematopoietic progenitors, and selected epithelial and immune cells. Because CD24 lacks conventional transmembrane and cytoplasmic domains, many of its functions depend on membrane-microdomain localization and interactions with neighboring receptors and glycan-binding proteins. The interaction between tumor-associated CD24 and Siglec-10 on myeloid cells has received particular attention as a potential innate immune-regulatory pathway capable of suppressing macrophage phagocytosis. CD24 is also frequently elevated in multiple epithelial tumors and has been associated with stem-like phenotypes, migration, and disease progression.

DIMA BIOTECH provides a full-length CD24 membrane-protein format together with multiple recombinant extracellular proteins for native-state binding analysis, ELISA, antibody screening, and epitope studies. Flow cytometry-validated monoclonal antibodies and conjugated formats support cell-surface CD24 detection and candidate benchmarking. Because CD24 is heavily glycosylated and membrane-context dependent, combining full-length membrane antigens with live-cell flow-cytometry validation provides a useful strategy for identifying antibodies that recognize physiologically relevant CD24 epitopes. In addition, to accelerate the development of CD24 biotherapy, DIMA BIOTECH has also prepared a CD24 target single B cell seed library, from which lead antibody molecules can be obtained in as fast as 28 days; at the same time, we have currently screened out multiple CD24 lead molecules, and customers can get the molecules for functional evaluation and verification the next day.